Autoresearch—the Karpathy-originated hill-climbing loop of small changes, binary testing, and iterative refinement—has matured from ML optimization into a generalizable pattern for prompt tuning, GPU experiments, web automation, and full research workflows. Claude-based agents now autonomously walk citation graphs, pull datasets, reformat data, launch training jobs, and retrain on failure (ml-intern beat Claude Code on GPQA 32% vs 22.99%); Feynman generates cited meta-analyses in 30 minutes and audits claims against code. The loop scales to planning (Sean Geng's plan-optimizer using Claude Fable 5 to break scoring ceilings) and adversarial research (grounding development in literature before building). Operationalized variants include the Evo plugin (open-source for Claude Code, auto-discovers metrics and runs tree search) and monthly wiki health checks that flag contradictions and unsourced claims. Power users are investing 1,200+ hours into Claude-based research workflows, indicating Claude is becoming a primary knowledge-work tool. At ~100 articles and ~400K words, LLMs handle complex Q&A against personal wikis via auto-maintained index files; filing results back creates compounding knowledge bases where every interaction enhances future queries rather than disappearing into chat history. The long-term trajectory involves synthetic data generation plus finetuning so LLMs "know" the data in weights rather than relying on context windows.